Metabolism of N6,02’-dibutyryl-3’,5’-cyclic-AMP (DBcAMP)

The effect of cyclic AMP and dibutyryl cyclic AMP on the permeability characteristics of the renal tubule.

The effect of adenosine-3',5'-cyclic monophosphate (cyclic AMP) and N(6),O(2)-dibutyryl adenosine-3',5'-cyclic monophosphate (dibutyryl cyclic AMP) on renal tubular permeability was studied by microinjection techniques in anesthetized diuretic rats. Radioactive inulin and mannitol were microinjected simultaneously into superficial proximal and distal convolutions and recovery of the isotopes wa...

Cyclic AMP metabolism in cholesterol-rich platelets.

The incorporation of cholesterol into human platelets by means of incubation with cholesterol-rich lecithin dispersions is associated with a decreased fluidity in the phospholipid hydrocarbon core of platelet membranes and an increased sensitivity of platelets to aggregating agents. We examined whether the platelet membrane enzyme, adenylate cyclase is influenced by changes in phospholipid flui...

آدنوزین منوفسفات حلقوی ( Cyclic AMP )

Induction of cyclic AMP phosphodiesterase in Blastocladiella emersonii and its relation to cyclic AMP metabolism.

Extracts of vegetative cells of Blastocladiella emersonii contain 5% or less of the cyclic AMP phosphodiesterase activity in zoospore extracts. This difference in activity could be accounted for entirely by an increase in the differential rate of phosphodiesterase synthesis during sporulation, beginning after a lag period of about 60 min and extending for at least an additional 90 min into the ...

Effects of dibutyryl cyclic AMP on patients with severe heart failure.

Dibutyryl cyclic AMP was administered to 2 patients with severe congestive heart failure. After an intravenous drip infusion of dibutyryl cyclic AMP (300 mg/40 min), marked diuresis and mild improvement of the patients' physical activity occurred. The cardiac index increased and both systemic vascular resistance and pulmonary capillary wedge pressure decreased. Blood glucose and plasma insulin ...